Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism

Nano-Micro Letters - Antibacterial activity of zinc oxide nanoparticles (ZnO-NPs) has received significant interest worldwide particularly by the implementation of nanotechnology to synthesize...     

"集成电路版图分析与设计"课程教改与探索

基于OBE-CDIO教育理念,本文展示了"集成电路版图分析与设计"课程教学模式、课程设计、项目式教学方式和课程考核方式改革探索与实践经验.我们以工程教学认证作为制定教学目标的依据,将BB平台、ISO9001等现代化教学资源和质量标准融入课堂,以OBE-CDIO能力教学理念指导课程设计,使教学环节科学化,考核环节多元化;通过引入课程思政,激发学生学习热情,树立核心价值观,增强版图分析设计能力.     

An approach for detecting the commonality and specialty between scientific publications and patents

Scientometrics - Scientific publications and patents are usually viewed as respective proxies of scientific research and technical development. There is considerable effort spent towards...     

A side-sensitive synthetic coefficient of variation chart

Control charts for monitoring the coefficient of variation (γ) are useful for processes with an inconsistent mean (μ) and a standard deviation (σ) which changes with μ, by monitoring the consistency in the ratio σ over μ. The synthetic-γ chart is one of the charts proposed to monitor γ, and its attractiveness lie in waiting until a second point to fall outside the control limits before a decision is made. However, existing synthetic-γ charts do not differentiate between the points falling outside the upper control limit (UCL) and lower control limit (LCL). Hence, this paper proposes a side-sensitive synthetic-γ chart, where successive nonconforming samples must either fall above the UCL or below the LCL. Formulae to compute the average run length (ARL), the standard deviation of the run length (SDRL) and expected average run length (EARL) are derived using the Markov chain approach, and the algorithms to obtain the optimal charting parameters are proposed. Subsequently, the optimal charting parameters, ARL, SDRL and EARL values for various numerical examples are shown. Comparisons show that the side-sensitive synthetic-γ chart consistently outperforms the existing synthetic-γ chart, especially for small shifts. The proposed chart also consistently outperforms the Shewhart-γ chart, while showing comparable or better performance than the Exponentially Weighted Moving Average (EWMA) chart for most shift sizes, except for very small shifts. Finally, this paper shows the implementation of the proposed chart on an industrial example.     

A Flexi-PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy

Near-infrared (NIR) activatable upconversion nanoparticles (UCNPs) enable wireless-based phototherapies by converting deep-tissue-penetrating NIR to visible light. UCNPs are therefore ideal as wireless transducers for photodynamic therapy (PDT) of deep-sited tumors. However, the retention of unsequestered UCNPs in tissue with minimal options for removal limits their clinical translation. To address this shortcoming, biocompatible UCNPs implants are developed to deliver upconversion photonic properties in a flexible, optical guide design. To enhance its translatability, the UCNPs implant is constructed with an FDA-approved poly(ethylene glycol) diacrylate (PEGDA) core clad with fluorinated ethylene propylene (FEP). The emission spectrum of the UCNPs implant can be tuned to overlap with the absorption spectra of the clinically relevant photosensitizer, 5-aminolevulinic acid (5-ALA). The UCNPs implant can wirelessly transmit upconverted visible light till 8 cm in length and in a bendable manner even when implanted underneath the skin or scalp. With this system, it is demonstrated that NIR-based chronic PDT is achievable in an untethered and noninvasive manner in a mouse xenograft glioblastoma multiforme (GBM) model. It is postulated that such encapsulated UCNPs implants represent a translational shift for wireless deep-tissue phototherapy by enabling sequestration of UCNPs without compromising wireless deep-tissue light delivery.     

基于贝叶斯思想的框架结构损伤检测方法研究* .txt

摘要：基于单自由度体系的统计矩理论，以位移四阶矩和加速度八阶矩为损伤指标，使用贝叶斯思想和Gibbs抽样相结合方法，提出一种框架结构损伤检测新方法。以理论分析为基础选取3种典型损伤指标，在信噪比40及30 dB环境噪音的不同损伤工况下，使用贝叶斯思想和Gibbs抽样相结合方法，对某12层标准框架数值模型的不同损伤指标进行了损伤识别效果的对比研究，并在此基础上与其他相似检测方法进行对比分析，发现使用贝叶斯思想和Gibbs抽样相结合的新方法，提出的损伤指标更适合框架结构损伤检测，与标准结果偏差均在5%以内。进一步分析12层标准框架振动台试验数据，选取3个典型振动工况中所有梁柱单元及前20个振动工况累积下的典型梁柱单元分别进行损伤检测，结果表明，所提方法避免了多次采样进行贝叶斯分析的局限性，且一定程度上能反映各损伤单元随振动台试验工况累积而表现出来的损伤程度变化，有助于推动所提方法在框架结构损伤检测中的实际应用。 .txt     

焊接线能量对高强钢焊接接头组织性能的影响

采用1.3、1.6、1.9 kJ/mm 3种不同线能量对960QT钢进行焊接，研究了线能量对960QT钢焊接接头组织和性能的影响。研究表明，随着线能量的增加，焊接接头强度下降，但塑性提高，焊缝冲击韧性变化不大，热影响区冲击韧性先降低后增大，热影响区冲击韧性均高于焊缝。对3种线能量下960QT高强钢的焊接接头进行金相分析，发现焊缝组织主要为针状铁素体和粒状贝氏体。随着线能量的增加，针状铁素体发生粗化，数量相对减少，粒状贝氏体数量增多。焊接接头热影响区的金相组织主要为板条M/B和粒状贝氏体。随着焊接线能量的增大，冷却速率减小，粒状贝氏体组织数量相对增加，而板条贝氏体组织的数量逐渐减少。     

海参废渣皂苷通过核苷酸结合寡聚化结构域样受体信号通路抵抗环磷酰胺诱导小鼠的免疫抑制

在我国海参是一种具有多种生物活性的传统滋补品。本实验系统性地研究了2.5、5.0、10.0 mg/（kg mb·d）海参废渣皂苷（saponins extracted from sea cucumber residues，SCRSS）对免疫抑制小鼠的调节作用。结果表明，与模型对照组相比，5.0 mg/（kg mb·d）SCRSS使小鼠的体质量、脾脏指数和胸腺指数分别增加了15.3%、23.8%和39.8%；5.0 mg/（kg mb·d）SCRSS也极显著增加了免疫抑制小鼠的吞噬指数（P＜0.01）。此外，与模型对照组相比，各剂量SCRSS均明显地增加了血清中细胞因子的水平，并促进了脾淋巴细胞和腹腔巨噬细胞的增殖活性。其中，中等剂量（5.0 mg/（kg mb·d））SCRSS可以更有效地上调免疫抑制小鼠核苷酸结合寡聚化结构域蛋白1、核苷酸结合寡聚化结构域蛋白2、受体相互作用蛋白-2和核因子-κB的表达。结论：SCRSS具有作为提高免疫力的功能性食品补充剂的潜力。     

Integrating Variable Reduction Strategy With Evolutionary Algorithms for Solving Nonlinear Equations Systems

Nonlinear equations systems (NESs) are widely used in real-world problems and they are difficult to solve due to their nonlinearity and multiple roots. Evolutionary algorithms (EAs) are one of the methods for solving NESs, given their global search capabilities and ability to locate multiple roots of a NES simultaneously within one run. Currently, the majority of research on using EAs to solve NESs focuses on transformation techniques and improving the performance of the used EAs. By contrast, problem domain knowledge of NESs is investigated in this study, where we propose the incorporation of a variable reduction strategy (VRS) into EAs to solve NESs. The VRS makes full use of the systems of expressing a NES and uses some variables (i.e., core variable) to represent other variables (i.e., reduced variables) through variable relationships that exist in the equation systems. It enables the reduction of partial variables and equations and shrinks the decision space, thereby reducing the complexity of the problem and improving the search efficiency of the EAs. To test the effectiveness of VRS in dealing with NESs, this paper mainly integrates the VRS into two existing state-of-the-art EA methods (i.e., MONES and DR-JADE) according to the integration framework of the VRS and EA, respectively. Experimental results show that, with the assistance of the VRS, the EA methods can produce better results than the original methods and other compared methods. Furthermore, extensive experiments regarding the influence of different reduction schemes and EAs substantiate that a better EA for solving a NES with more reduced variables tends to provide better performance.      

采用QuEChERS结合UHPLC-MS/MS定量分析热加工肉制品中的三种胺类物质

本文采用QuEChERS技术结合超高效液相色谱-串联质谱（UHPLC-MS/MS）技术建立同时检测丙烯酰胺（AA）、亚硝胺（NAs）和杂环胺（HAAs）含量的方法，用于分析热加工肉制品中产生的胺类物质。结果表明:该方法检测出的三类成分20种胺类物质在相应浓度范围内显示出良好的线性关系（R2>0.991），检测限和定量限分别为0.01~1.6 ng/g和0.03~4.8 ng/g，日内回收率介于66.3%~116.5%之间，日内精密度介于0.78%~9.0%之间。每个胺类物的5×LOQ加标水平计算的日间精度范围为3.4%~9.4%。该方法应用于煎烤的四种肉制品中AA、NAs和HAAs的分析，共检测出9种胺类物质，浓度范围为0.03~31.26 ng/g。